Research in Ontario & Nunavut

Researchers

Project Title
Researcher
Research Area
Affiliation
Funding Term
Funding
Sex and Central Nervous System Autoimmunity Dr. Shannon Dunn Cause and Risk Factors Toronto General Research Institute 2016-2019 $346 896
Coming off cannabis in MS: a longitudinal, cognitive and fMRI study. Dr. Anthony Feinstein Symptom Mangement and Quality of Life Sunnybrook Research Institute 2015-2018 $282 227.80
A multi-site randomized controlled trial of MS INFoRM: An interactive fatigue management resource for persons with MS Dr. Marcia Finlayson Symptom Mangement and Quality of Life Queen's University 2017-2020 $268 789.83
Circadian control of pain and neuroinflammation in experimental autoimmune encephalomyelitis Dr. Nader Ghasemlou Symptom Mangement and Quality of Life Queen's University 2018-2021 $308 134
Immune cell-microbiome interactions and neuroinflammation Dr. Jennifer Gommerman Mechanisms of Disease - Progression University of Toronto 2016-2019 $365 500
The Role of Antibody-Secreting Cells in MS/EAE Dr. Jennifer Gommerman Mechanisms of Disease - Mechanisms of Progression University of Toronto 2018-2021 $370 500
MicroRNA-145 is a key regulator of oligodendrocyte maturation and CNS myelination Dr. Rashmi Kothary Mechanisms of Disease - Repair Ottawa Hospital Research Institute 2017-2020 $301 920
A double-blind placebo controlled study of mixed-amphetamine salts, extended release (Adderall XR) for cognitive impairment in MS Dr. Sarah Morrow Therapy and Clinical Tool Development Western University 2016-2019 $161 325
Defining a dual role for VGF in the regulation of MS pathology Dr. David Picketts Mechanisms of Disease - Repair Ottawa Hospital Research Institute 2018-2021 $312 528
Functional electrical stimulation cycling for managing mobility disability in people with multiple sclerosis Dr. Lara Pilutti Symptom Mangement and Quality of Life University of Ottawa 2018-2021 $294 450
Immigration and the risk of multiple sclerosis Dr. Dalia Rotstein Cause and Risk Factors University of Toronto 2017-2019 $102 774.64

Trainees

Project Title
Trainee
Affiliation
Award
Research Area
Project Description


Physical Activity Together for MS: Pilot Study of a Dyadic Telerehabilitation Intervention for People with Moderate-to-Severe Multiple Sclerosis Disability and their Family Caregivers Afolasade Fakolade University of Ottawa Postdoctoral Fellowship Symptom Management and Quality of Life The project will determine the feasibility and effects of a dyadic physical activity intervention on physical activity levels, and mobility, cognition, self-efficacy, caregiver burden, coping and quality of life in people with MS and their caregivers.
Advanced in vivo imaging of disease causing T and B cells in a model of anti-myelin autoimmunty Kate Parham Western University Postdoctoral Fellowship Mechanisms of Disease - Nerve Damage & Triggers of MS In MS, components of the immune system interact/talk to each other and then begin to attack myelin in the central nervous system. This study will visualise these interactions, revealing specific targetable characteristics of a MS autoimmune response.
Enhancing the Safe Mobility of Individuals with Multiple Sclerosis by Advancing Approaches to Ambulatory Monitoring and Gait Biofeedback Training Justin Chee University of Toronto Studentship PhD Symptom Management and Quality of Life This research aims to build a smart rollator for persons with MS that: delivers feedback-enhanced personalized training exercises to prolong their ability to walk; improves how disease progression is tracked; and augments their community integration
Evaluation of the role of peroxisome-proliferator activated receptor delta (PPARd) in microglial responses during experimental autoimmune encephalomyelitis (EAE) Paulina Drohomyrecky University of Toronto Studentship PhD Cause and Risk Factors This project will evalaute the role of a protein, called PPARδ, which is known to be involved in immune regulation. Specifically, the aim is to determine if PPARδ alters the function of immune cells of the brain, called microglia.
Investigating the neuronal oscillatory properties of the dynamic pain connectome in chronic pain patients with MS: A magnetoencephalography study Junseok Kim University of Toronto Studentship PhD Symptom Management and Quality of Life The project will use imaging to investigate the brain activity in different brain regions and investigate differences in brain activity in people with MS who suffer from chronic pain.
Uncovering and reversing causes of remyelination failure in progressive multiple sclerosis - miR-145-5p regulates MYRF in oligodendrocytes Samantha Kornfeld Ottawa Hospital Research Institute Studentship PhD Mechanisms of Disease - Progression The study aims to discover and understand molecules in the progressive MS lesions that block repair processes. By understanding the effects these molecules have, new methods to overcome them to allow remyelination to occur can be developed.
Identifying pathogenic B cells in an animal model of central nervous system autoimmunity and determining their susceptibility to therapeutic depletion Yodit Tesfagiorgis University of Western Ontario Studentship PhD Mechanisms of Disease - Progression The goal of this project is to understand what an immune cell, called the B cell, is doing both throughout the body and specifically in the brain and spinal cord to contribute to multiple sclerosis incidence and severity.
Elucidating the role of PPARd expression in microglial cells during EAE Ellinore Doroshenko University Health Network - Toronto General Hospital Research Institute Studentship Msc Mechanisms of Disease - Progression The project focuses on microglia, the immune cells that home the brain and spinal cord, and looks at how they act within a mouse model of MS-like disease.
Memory and Social Cognition in Pediatric-Onset Multiple Sclerosis Tracy Fabri York University Studentship Msc Symptom Management and Quality of Life To explore the relationship between memory and identification of emotional expression in pediatric-onset MS and how volume of a brain region called the amygdala (facilitates threat response, regulates memory and identification of facial emotional expressions) mediates this relationship.
Evaluating relationships between structural and functional visual pathway abnormalities in youth with demyelination: Visual evoked cortical magnetic responses and Optical Coherence Tomography (OCT) Riyeon Kim The Hospital for Sick Children Studentship Msc Therapy and clinical tool development The project investigates functional changes in vision caused by injury to the visual pathway observed from MS patients using visual evoked potential. This study will establish new knowledge about markers of disease activity for future clinical trials.
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